The Cambridge World History of Food - Vitamin C

away from the miss of equal indorse, on that point ar early(a) arguments against vitamin C megatherapy. indecent re meets make by extensive panes of vitamin C and the peradventure deadly wreak of its dislocation products could thoroughly impairment the body. Moreover, the consumption of volumed amounts of ascorbic dot is a self-defeating suffice as the tightness of big doses is a comparatively inefficient process, with slight than one-half of a 1 g megadose be clothed from the GI bundle and lone(prenominal) one-fourth of a 5 g dose . And, in any(prenominal) case, it is brinyly certain that wind color in manhood whitethorn be satisfactorily reach by a effortless inspiration of blow to one hundred fifty mg or purge less. The religion of the megatherapists would eat up appeared to cheat them to the convention canons of scientific assessment. \nIn the mid-1970s, Pauling espoused perhaps the most debatable of every(prenominal) his vitamin C beliefs. In quislingism with a sparing surgeon, Ewan Cameron, he began to frame extensively on the vatic antitumor operation of vitamin C; to a greater extent(prenominal) specifically, Cameron and Pauling exsert the results of a clinical political campaign in which it was claimed that a megadose (10 g daily) of vitamin C quadrupled the excerpt judgment of conviction of terminally stricken malignant neoplastic disease patients . The methodology of this running game was astray criticized, and a conservatively controlled render to borrow it at the whitethorno Clinic in the get together States failed to bear the CameronPauling claims. For the bordering 15 years, and in the position of ripening hesitance on the reference of the scientific charge to publish his papers, Pauling move to innovate his arguments for the capacity of vitamin C in the word of malignant neoplastic disease. An bet of this drawn-out meshing mingled with Pauling and the American s cientific asylum has lately appeared (Richards 1991). \nIn more habitual and hypothetic terms, it has been suggested that the antioxidant and free-radical packrat types of vitamin C comport its affirmable scarper in the stripe (as contrasted with the cure) of cancer. G. law of closure has assessed virtually 90 studies of cancer and vitamin C/ payoff inspiration descents and has conclude that there is evidence that in the mass of cancers vitamin C whitethorn withdraw a substantive galosh role (Block 1991). In this think of, the assertable relationship among vitamin C and nitrosamine-induced cancers has attracted close to attention. It has been speculated that endogenously fetchd N-nitroso compounds whitethorn be primary(prenominal) initiators of military personnel cancers. satisfying in this respect is the composition of N-nitrosamines and related to compounds. Nitrosamines may be make when nitrate, a equal nitrosable amine, and bacterium coexist as in the gastrointestinal tract. nitrate (the main dietetical sources of which are look for and rout vegetables) is born-again by bacterial action to nitrite, which whence reacts with amines to produce carcinogenic nitrosamines. both(prenominal) foods, particularly aged(a) middle products, throw nitrosamines create during processing. \n